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Emerging from the protective environment of the uterus, the newborn is exposed to a myriad of microbes, and quickly establishes a complex microbiome that shapes the infant’s biology in ways that are only now beginning to come to light. Among these exposures are a number of potential pathogens. The host responses to these pathogens in the neonatal period are unique, reflecting a developing immune system even with delivery at term. Preterm infants are delivered at a time when host defense mechanisms are even less developed and therefore face additional risk. As such, the organisms that cause disease in this period are different from the pathogens that are common in other age groups, or the disease they cause manifests in more severe fashion. Developmental alterations in both innate and adaptive immune responses in neonates have been documented among many cell types and pathways over the last several decades. Contemporary insights into the human immune system and methodologies that allow an “omics” approach to these questions have continued to provide new information regarding the mechanisms that underlie the human neonate as an “immunocompromised host.” This Research Topic highlights studies related to this unique host-pathogen interface. Contributions include those related to the innate or adaptive immune system of neonates, their response to microbial colonization or infection, and/or the pathogenesis of microbes causing disease in neonates.
Infection --- Neonate --- Candida --- Sepsis --- Necrotizing enterocolitis --- Vaccine --- Immunity --- Microbiome
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Neuropathology --- Nervous system --- Newborn infants --- Diseases. --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- Nervous Systems --- System, Nervous --- Systems, Nervous
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Infant, Newborn. --- Infant, Newborn, Diseases. --- Neonatal Diseases --- Disease, Neonatal --- Diseases, Neonatal --- Neonatal Disease --- Perinatology --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- infant --- newborn --- diseases --- Geriatrics --- gerontologie --- neonatologie
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Infant Care --- Infant, Newborn --- Neonatal Nursing --- Nursing Care --- methods --- Infants --- Newborn infants --- Pediatric nursing --- Pediatric nursing. --- Infant, Newborn. --- Care --- Care. --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Children --- Infants (Newborn) --- Baby care --- Infant care --- Newborns (Infants) --- Diseases --- Nursing --- Care and hygiene --- Neonatology --- Neonatal Nursing. --- Nursing, Neonatal --- Nursing, Perinatal --- Perinatal Nursing
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Pediatric neurology. --- Brain Diseases. --- Infant, Newborn. --- Nervous system --- Neurology --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Diseases
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Critical congenital heart defects (CCHDs) are potentially life-threatening malformations that remain a significant cause of neonatal mortality and morbidity. Failure to diagnose these conditions shortly after birth may result in acute cardiovascular collapse and death. The identification of CCHDs by routine newborn clinical examination is routine in many countries, but consistently misses over a third of cases, and, although antenatal ultrasound screening can be very effective in early diagnosis, the provision and accuracy of ultrasound screening is highly variable. As most CCHDs present with mild cyanosis (hypoxaemia), which is frequently clinically undetectable, pulse oximetry is a rapid, simple, painless method of accurately identifying hypoxaemia, which has gained popularity as a screen for CCHD. This Special Issue of the International Journal of Neonatal Screening, devoted to ""Neonatal Screening for Critical Congenital Heart Defects (CCHDs)"", will consider the evidence for CCHD screening with pulse oximetry, the acceptability and cost-effectiveness of this intervention, the additional non-cardiac conditions which it may also identify, and international experiences of introducing CCHD screening across the globe.
n/a --- altitude --- CCHD screening in the US --- screening --- coarctation of aorta --- oxygen saturation --- neonates --- critical congenital heart disease screening --- newborn screening pulse oximetry --- home births --- health policy --- congenital heart disease --- neonatal screening --- pulse oximetry --- cost-effectiveness --- hypoxia --- neonate --- newborn --- critical congenital heart disease --- state screening --- pulse oximetry screening --- economic evaluation --- screening algorithm --- newborn screening --- Germany --- congenital heart defects
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Individualized Medicine --- Pediatrics --- Periodicals. --- Neonatology --- Personalized medicine --- Precision Medicine. --- Pediatrics. --- Neonatology. --- Child. --- Infant, Newborn. --- Personalized medicine. --- Individualized medicine --- Paediatrics --- Pediatric medicine --- Neonatal pediatrics --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Children --- Personalized Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- medicine --- pediatrics --- neonatology --- metabolomics --- individualized medicine --- Medical care --- Pharmacogenetics --- Medicine --- Perinatology --- Newborn infants --- Minors --- Pharmacogenomic Variants --- Patient-Specific Modeling --- Diseases --- Health and hygiene --- P Health --- P-Health --- P-Healths --- Theranostics --- Predictive Medicine --- Medicine, Predictive --- Theranostic --- Precision medicine
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The first edition of Color Atlas of Fetal and Neonatal Histology was an important step in updating the histology texts available to practicing pathologists and pathology trainees who perform fetal autopsy and/or participate in research involving fetal tissues. It was a well-received volume that filled a major gap in pathology references related to normal histology and provided a comprehensive, state-of-the art review of fetal and neonatal histology. While the basics of fetal histology have changed little in the intervening years since publication of the first edition, this successor edition provides new insights and a fresh perspective. This book contains six new chapters including: blood vessels and lymphatics, external genitalia, eye, ear, skin, and maceration changes. Many existing chapters have also been expanded to address a greater breadth of fetal and neonatal histology such as postnatal testis development and the cardiac conduction system. The “Special Considerations” sections were also expanded in many chapters to address particularly problematic issues within individual organ systems. The book reviews the histology of the major organ systems in the fetus and neonate and provides detailed images, up-to-date references, and practical guidelines for identifying tissues across all gestational ages of development. The second edition of Color Atlas of Fetal and Neonatal Histology serves as the ultimate go-to resource for pathologists and researchers dealing with, and interested in, fetal and neonatal histology. It provides a comprehensive summary of the current status of the field with excellent and extensive illustrative examples that help guide the clinical study of fetal and neonatal histology and stimulate investigative efforts with fetal tissue. .
Histology --- Pathology. --- Pediatrics. --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Health and hygiene --- Fetus. --- Newborn infants. --- Infant, Newborn --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- Fetal Tissue --- Fetuses --- Mummified Fetus --- Retained Fetus --- Fetal Structures --- Fetal Structure --- Fetal Tissues --- Fetus, Mummified --- Fetus, Retained --- Structure, Fetal --- Structures, Fetal --- Tissue, Fetal --- Tissues, Fetal --- Embryo, Mammalian --- Fetal Research --- Infants (Newborn) --- Newborns (Infants) --- Infants --- Foetus --- Unborn child --- Embryology --- Reproduction
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A must-have reference for the entire NICU, Goldsmith’s Assisted Ventilation of the Neonate, 7th Edition, is the only fully comprehensive, evidence-based guide to all aspects of this fast-changing field. Easy to use and multidisciplinary in scope, this trusted reference provides authoritative guidance on contemporary management of neonatal respiratory diseases, with an emphasis on evidence-based pharmacologic and technologic advances that improve outcomes and quality of life in newborns. It’s an outstanding resource for neonatologists and NICU professionals to acquire new knowledge and techniques in this critical area of neonatal care.
Respiratory therapy for newborn infants. --- Artificial respiration. --- Respiration, Artificial --- Inhalothérapie pour nouveau-nés. --- Respiration artificielle. --- Infant, Newborn, Diseases --- Infant, Newborn --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- methods --- therapy --- Newborn infants. --- Infants (Newborn) --- Newborns (Infants) --- Infants --- Artificial ventilation (Therapy) --- Mechanical ventilation (Therapy) --- Pulmonary resuscitation --- Rescue breathing --- Ventilation, Mechanical (Therapy) --- First aid in illness and injury --- Respiratory therapy --- Resuscitation --- Neonatal respiratory therapy --- Newborn respiratory therapy --- Newborn infants
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Surgical Procedures, Operative --- Child. --- Infant. --- Surgery, Operative --- Children --- Chirurgie opératoire --- Enfants --- Periodicals. --- Periodicals --- Surgery --- Périodiques --- Chirurgie --- Surgical Procedures, Operative. --- Surgery. --- neonate --- infants --- children --- oncology --- thoracic surgery --- neurosurgery --- Infants --- Minors --- Ghost Surgery --- Operative Procedures --- Operative Surgical Procedure --- Operative Surgical Procedures --- Procedure, Operative Surgical --- Procedures, Operative Surgical --- Surgery, Ghost --- Surgical Procedure, Operative --- Operative Procedure --- Procedure, Operative --- Procedures, Operative --- General Surgery --- Pediatric surgery --- Surgery, Pediatric --- Childhood --- Kids (Children) --- Pedology (Child study) --- Youngsters --- Age groups --- Families --- Life cycle, Human --- Diseases --- Treatment --- Surgical Procedures --- Procedure, Surgical --- Procedures, Surgical --- Surgical Procedure --- pediatric surgery --- pediatrics --- neonatology
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